Further clinical studies will confirm if a long term treatment with MX3 can improve knee joint function and reduce discomfort on subjects showing symptoms of osteoarthritis. Mangosteen Garcinia mangostana Linn is a tropical fruit that has been used as a traditional indigenous medicinal material across Southeast Asia Thailand, Malaysia, Taiwan, Philippines, Indonesia, and Sri Lanka for treatment of a wide range of ailments including trauma, diarrhea and skin infections, wound healing, and related gastrointestinal complaints.
More recently a group of secondary metabolites known as xanthones have been isolated from the pericarp of the mangosteen Garcinia mangostana and are attributed the medicinal and health beneficial properties of the fruit Various health-promoting activities of xanthones in the pericarp of Garcinia mangostana have been observed in vitro.
However, controlled trials to observe the efficacy of these xanthones in human subjects, as well as the effect on several ailments, is very limited. LTFI , a Global importer of organic products. This material has been standardized by the amount of xanthones with the proper regulations for microbial and heavy metals required to meet industrial standards. MX3 supplement was tested in subjects with self-reported knee discomfort, randomized and blinded for treatment with either a twice daily dose of mg daily dose of MX3 Group 1 , a single daily dose of mg MX3 Group 2 or a once a day daily dose of placebo Group 3 during a 28 day period.
Subjects were recruited for this study on the basis of a pre-existing knee joint discomfort, no shorter than 3 weeks and not related to injury. Subjects were not medically diagnosed prior to the study. The selection criterion was based on the results from the McGill Pain Questionnaire, which estimates the level of pain subjectively These questionnaires were given to the subjects at day zero beginning of the study , day 10 and day Placebo material was provided by DMI.
Previous to the beginning of the protocol, all participants signed an informed consent. Thirty-six subjects with self-reported joint discomfort were recruited for this study. Other than joint discomfort, participants were generally healthy and had no diagnosis of any respiratory tract infections, diabetes, or dietary allergies. Participants were advised to abstain from taking vitamin D, testosterone supplements, or steroid- containing over the counter or prescribed medications for 30 days before the study period.
During the study period, participants ingested only MX3 or placebo. Subjects were supplied with capsules containing either mg of MX3 or mg of Placebo material. Capsules and containers had the same appearance and were only differentiated by a code, to keep the subjects blind. The treatments were distributed as follows: Group one took a twice daily dose of mg daily dose of MX3, group 2 had a single daily dose of mg MX3 and group 3 had a once a day daily dose of placebo Group 3 during a 28 day period.
Subjects were advised to take the first or single dose in the morning, before the first meal, with water. The WOMAC consists of 24 items divided into 3 subscales; which include pain 5 items; scores range from 0 to 20 , stiffness 2 items; scores range from 0 to 8 , and functional limitations 17 items; scores range from 0 to Total scores range from 0 best to 96 worst.
The scale contains 4 subscales consisting of 78 words that participants use to indicate feelings of pain. Seven words are chosen from categories of pain description, pain components, evaluation of pain, and a miscellaneous descriptor. Each chosen word has an associated numerical value, and total scores range from 0 no pain to 78 severe pain. The McGill pain questionnaire was administered on day 1 pre-treatment and after 5 and 10 days of treatment. Statistical comparison samples previous and post- treatment, within and between groups were made using Graphpad Prism 6 Version 6.
A Chi-square test was performed to determine if the data sets had a normal distribution. Normally distributed data was analysed using a paired two sample t test. P values less than 0. However, it was not significant mean It was significant when compared to placebo mean When compared to placebo, group 2 was significant mean Data is presented as ratio percent difference over baseline with SE of the mean in figure 1. Ratio was calculated based on the day 0.
It was not significant mean Data is presented as ratio percent difference over baseline with SE of the mean in figure 2. McGill Score after 10 and 28 days of treatment.
The xanthones found in mangosteen may play a role in reducing inflammation. Test-tube and animal studies suggest that xanthones have an anti-inflammatory effect and may reduce your risk of inflammatory diseases, such as cancer, heart disease, and diabetes 9.
Mangosteen is also rich in fiber, which offers various benefits. Though this data is encouraging, more research is needed to better understand how mangosteen affects inflammation and disease progression in humans.
Plant compounds and fiber in mangosteen may have anti-inflammatory effects according to animal research. More studies are needed to understand how this fruit may reduce inflammation in humans. Population studies show that diets rich in vegetables and fruits like mangosteen are associated with reduced incidences of cancer Specific plant compounds in mangosteen — including xanthones — have antioxidant and anti-inflammatory effects, which may help fight the development and spread of cancerous cells 9 , Multiple test-tube studies reveal that xanthones can inhibit cancer cell growth, including in breast, stomach, and lung tissue Similarly, a small number of studies observed that this compound may slow the progression of colon and breast cancer in mice Test-tube and animal research indicates that xanthones in mangosteen may protect against cancer.
However, high-quality human research on this topic is lacking. One study found that mice on a high-fat diet who received supplemental doses of mangosteen gained significantly less weight than mice in the control group Similarly, in a small, 8-week study, people who supplemented their diets with 3, 6 or 9 ounces 90, , or ml of mangosteen juice twice daily tended to have a lower body mass index BMI than the control group Ultimately, more studies are needed to better understand how mangosteen may fit into an effective weight loss plan.
Some animal and human research suggests that mangosteen may play a role in weight loss and obesity prevention. Still, more studies are needed. Both test-tube and animal studies show that xanthone compounds in mangosteen may help you maintain healthy blood sugar levels A recent week study in obese women found that those receiving mg of supplemental mangosteen extract daily had significant reductions in insulin resistance — a risk factor for diabetes — compared to the control group The fruit is also a good source of fiber, a nutrient that can help stabilize blood sugar and improve diabetes control The combination of the xanthone and fiber contents in mangosteen may help balance blood sugar.
However, more research is needed. Plant compounds and fiber in mangosteen may contribute to reduced blood sugar. Still, current research is insufficient. Fiber and vitamin C — both of which can be found in mangosteen — are important for a healthy immune system 1. Fiber supports your healthy gut bacteria — an essential component of immunity. On the other hand, vitamin C is needed for the function of various immune cells and has antioxidant properties 17 , Additionally, some research suggests that certain plant compounds in mangosteen may have antibacterial properties — which could benefit your immune health by combating potentially harmful bacteria In a day study in 59 people, those taking a mangosteen-containing supplement experienced reduced markers of inflammation and significantly greater increases in healthy immune cell numbers compared to those taking a placebo Your immune system requires many different nutrients to function optimally.
Mangosteen may be a healthy choice to include alongside other nutrient-dense foods as part of a balanced diet. Research suggests that mangosteen may increase your number of immune cells and reduce inflammation — potentially boosting immune health. Skin damage from sun exposure is a common occurrence worldwide and a major contributor to skin cancer and signs of aging One study in mice treated with supplemental mangosteen extract observed a protective effect against ultraviolet-B UVB radiation in the skin Research suggests that antioxidant and anti-inflammatory compounds in mangosteen may protect skin cells from damage associated with sun exposure and aging.
Research suggests that nutrients and other plant compounds in mangosteen may support optimal digestive, heart, and brain function. Mangosteen is easy to prepare and eat — though it may be difficult to find depending on where you live. Your best bet is to look for it at specialty Asian markets, but be aware that fresh mangosteen can be quite expensive. Frozen or canned forms may be cheaper and easier to find — but be mindful that canned versions often contain added sugar.
If you happen to score a fresh supply, choose fruits with a smooth, dark purple outer rind. The rind is inedible but can be easily removed with a serrated knife. The inner flesh is white and very juicy when ripe. Customer Login If you are already registered, please log in. Email Address:. Forgot your password? Create your account and enjoy a new shopping experience.
Create a new account. Buy 1 Get 1. Rating Required Select Rating 1 star worst 2 stars 3 stars average 4 stars 5 stars best. Email Required. Review Subject Required. Comments Required. You save. Current Stock:. Brand MX3. This product hasn't received any reviews yet. Be the first to review this product! Write a Review. We will deliver orders in the following areas except in island barangays. There are two 2 ways to receive your order: a via Home Delivery b via Store Pickup in any of the following St.
Cruz, Zambales 3. Additional amount will be charged depending on the distance of the shipping address you specified please refer to the Shipping Fee Directory. Store Pickup Free of Charge 4. We will deliver your order as follows: a for Home Delivery Orders Received Delivery Schedule Before pm Same day delivery within pm to pm After pm Next day delivery within pm to pm b for Store Pick-up You may expect your order to be ready within 2 hours to a day depending on the availability of ordered item upon placement of order.
We will deliver your order from Monday to Sunday including holidays from pm to pm. There are two 2 ways to track your order: a For every change in the order status, an email will be sent to you. However, if payment was made via bank transfer, your representative shall be required to present the following: a Authorization Letter; and b Your Valid ID with picture and signature and that of your representative. Joseph Drug official receipt Note : We may require additional documents e.
Joseph Drug Perez Blvd. Neque porro quisquam est qui dolorem ipsum quia dolor sit amet Lorem ipsum dolor sit amet, consectetur adipiscing elit. Phasellus magna enim, placerat non lacus varius, cursus consectetur urna Phasellus finibus nulla vitae malesuada efficitur. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus Suspendisse imperdiet enim in porttitor dignissim. Related Products. Ampalaya Plus Banaba mg 1 Capsule.
Customers Also Viewed. Natalac mg 1 Capsule. SJ Greencard. Alanerv mg 1 Capsule. MX3 Coffee Mix 10g 1 Sachet. Sleepwell 3mg 1 Capsule. Be a member. Ask the Expert anything on Beebies store We will follow up with you via email within hours.
0コメント